techniques to treat neurological disorders by attenuating the production of proinflammatory mediators

摘要

"Techniques for treating neurological disorders by mitigating the production of proinflammatory mediators". The present invention relates to methods and devices for attenuating tumor necrosis factor (TNF) and other proinflammatory mediators in the CNS for treating brain injury, pain, and neuropsychiatric, neurodegenerative, neurological disorders. More particularly, TNF blocking agents that target intracellular signals and downstream effects associated with TNF production and secretion are described. The described devices include therapy delivery devices comprising a reservoir capable of housing a TNF blocking agent and a catheter operably coupled to the device and adapted to deliver the TNF blocking agent to a target site within an individual.