combination of a farnesyl transferase inhibitor with an antihormonal agent for the treatment of breast cancer

摘要

"COMBINATION OF A FARNESIL INHIBITOR TRANSFERS WITH AN ANTIHORMONAL AGENT FOR BREAST CANCER TREATMENT". The present invention relates to a method for treating breast cancer. The method comprises administering a farnesyl transferase inhibitor (FTI), at least one antihormonal agent (e.g., an aromatase inhibitor, an antiestrogen, and an LHRH analog), optional chemotherapeutic agents (eg Trastuzumab), and optional radiation. . For example, treatment of breast cancer using farnesyl transferase inhibitor and Anastrozole is disclosed. Also disclosed is a method for treating breast cancer using farnesyl transferase inhibitor Anastrozol and Fulvestrant. Further disclosed are pharmaceutical compositions comprising a farnesyl transferase inhibitor, at least one antihormonal agent and a pharmaceutically acceptable carrier; and compositions comprising a farnesyl transferase inhibitor, at least one antihormonal agent, at least one chemotherapeutic agent, and a pharmaceutically acceptable carrier; and compositions comprising a farnesyl transferase inhibitor, at least one chemotherapeutic agent, and a pharmaceutically acceptable carrier.