composition of labdane diterpenes extracted from andrographis paniculata, useful for the treatment of autoimmune diseases, and alzheimer's disease by ppr-gamma receptor activation

摘要

"LABDANO COMPOSITION DIPERPENES EXTRACTED FROM ANDROGRAPHIS PANICULATA, USEFUL FOR TREATMENT OF AUTOMUNE DISEASES, AND ALZHEIMER DISEASE BY ACTIVATION OF PPR-GAMMA RECEPTORS". The present invention relates to a composition consisting of molecules identified as diterpene labdanes, which are obtained from valuable plant species of Andrographis paniculata, dried grass by a special extraction process for the treatment of non-autoimmune immunological diseases. immune effects in humans and animals, exhibiting low toxicity and absence of significant side effects. Similarly, the novel composition is useful for preparing a pharmaceutical composition useful for preventing and treating Alzheimer's disease. The composition inhibits the synthesis of proinflammatory cytokines as a result of PPAR gamma receptor activation and decreased kappa nuclear factor B. In addition, by its own therapeutic characteristics, this new composition resolves the drawbacks of the drugs, procedures and products that have a significant level of toxicity and / or cause unwanted side effects. The present invention has applications in immunopharmacology, preclinical and clinical veterinary and human pharmacology, pharmaceutical technology, rheumatology, and clinical immunology, immunotherapy, tissue and organ transplantation, and immunodeficiency diseases such as AIDS.