compound, pharmaceutical composition, use of a compound, and methods of treating a androgen-treatable condition, disorder or disease, treating an androgen receptor-related condition, disorder or disease and male contraception

摘要

COMPOUND, PHARMACEUTICAL COMPOSITION, USE OF A COMPOUND, AND METHODS OF TREATMENT OF A CONDITION, DISORDER OR DISEASE TREATED WITH ANDROGEN, TREATMENT OF A CONDITION, DISORDER OR DISEASE RELATED TO THE PRESENT CONCRETE CONCEPTION AND DISEASE a structure according to formula I: wherein X is S or SO-2 ~; R¬ 1¬ is (1C-6C) alkyl, (3C-6C) alkenyl, or (3C-6C) alkynyl, each optionally substituted with (3C-6C) cycloalkyl, OH, OC (O) (1C-4C) ) alkyl, (1C-4C) alkoxy, halogen, cyano, formyl, C (O) (1C-4C) alkyl, CO-2H, CO-2- (1C-4C) alkyl, C (O) NR¬ 5¬R¬6¬, S (O) (1C-4C) alkyl or S (O) -2- (1C-4C) alkyl; R¬ 2¬ is hydrogen, (1C-4C) alkyl or C (O) (1C-4C) alkyl, R¬ 3¬ is a phenyl group optionally substituted with (1C-4C) alkyl, (1C-4C) fluoroalkyl, (IC-4C) alkoxy, (1C-4C) fluoroalkoxy, halogen, cyano or nitro; or R¬3¬ is a 5- or 6-membered aromatic heterocyclic ring structure optionally substituted with (1C-4C) alkyl, (1C- (4C) fluoroalkyl, (1C-4C) alkoxy, halogen or cyano; is a phenyl group or a 6-membered aromatic heterocycle substituted ortho by 1-hydroxy (1C-4C) alkyl, (1C-4C) alkoxy, C (O) (1C-4C) alkyl, CO-2 ~ ( (C 1 -C 4) alkyl, C (O) NH 2 -, cyano, nitro, or CH-NOR¬ 7¬, and optionally further substituted by (1C-2C) alkyl, (1C-2C) fluoroalkyl or halogen; 5¬ is 2-pyridyl optionally substituted with (1C-2C) alkyl, (1C-2C) fluoroalkyl or halogen, or R¬ 5¬ and R¬ 6¬ are independently hydrogen or (1C-4C) alkyl; 7¬ is hydrogen or C (O) (1C-4C) alkyl, R¬ 8¬, R¬ 9¬, R¬ 10¬ are independently hydrogen, (1C-2C) alkyl, fluorine or chlorine, or a salt or hydrate form thereof.