Quinoline derivatives as inhibitors of PDE, Selective phosphodiesterase 4B

摘要

1.A compound of formula (i) or a pharmaceutically acceptable Salt thereof, wherein R1 is C1 - C3 alkyl or cycloalkyl - 6; 7 cicloalquil C3 - 7 (c1-4 alkyl and cycloalkyl) - 7 pp. ISBN is optionally substituted with one or more substituents selected from cycloalkyl = o and Oh; C4 - 7 A Thickened Ring aryl aryl (alkyl, aryl or C1 - 6) - Where the aril is optionally substituted with aOr more alkyl substituents selected from C1 - 6, 6 - conr6 - alkyl - C1, C1 - 6 - CO alkyl, halogen, - CF3, - (CH2) MOH, ocf3 C1 - alkoxy -, 6 -, alkoxy C1 - 6 (c1-4 alkyl alkoxy) - C1 - 6 - 6 - alkoxy - C2, C1 - 6 - alkoxy carbonyl, - CN, - r4r5nco, r7r8n, r9r10nconr11 Ho - (CH2) 2 -, 6 -, r12r13nso2 (CH2) M - (4 - morphological Inil) - C2 - 6 - alkoxy alkyl, nr14so2 C1 - 6, ariloxi,(optionally substituted heteroaryl alkyl C1 - 6), CO2H, r21r22n - (alkyl c1-4 alkoxy) - 6 - conr23 C1 - (CH2) M - (optionally substituted aryl, alkyl aryl C1 - 6); condensate cycloalkyl Ring with a C4 - 7, where the ring is optionally substituted cycloalkyl one or more = aryl or; Heterociclilo condensate with a ring,Where the heterociclilo ring is optionally substituted with one or more substituents selected from = or COC c1-4 alkyl and alkyl c1-4, heteroaryl heteroaryl alkyl - or - C1 - 6), where the heteroaryl is optionally substituted with one or more alkyl substituents selected from: C1 - 6 - (alkyl, aryl c1-4 alkoxy, halogen, C1 - 6C1 - 6 - alkoxy optionally co; or heterociclilo condensate with an aryl or heteroaryl ring. R2 is Hydrogen or alkyl of C1 - 6; R34 is a group of formula: in which R1 - R3 is rent 6 optionally substituted with one or more substituents selected from - Oh, nr16cor15,...