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Recombinant Sendai virus vector to introduce exogenous genes into airway epithelium
Recombinant Sendai virus vector to introduce exogenous genes into airway epithelium
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机译:重组仙台病毒载体将外源基因导入气道上皮
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摘要
Provided are a recombinant Sendai virus vector for introducing exogenous genes to airway epithelia and a method for introducing exogenous genes using the vector. The recombinant Sendai virus vector enables efficient gene transfer to native mucus-layered airway epithelial cells by briefly contacting the vector with the cells. Furthermore, the vector can introduce genes to not only apical surfaces but also submucosal glands where CFTR primarily expresses. The vector can thus be used for gene therapy of CF, a CFTR-deficient disease.
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