METHOD FOR PREPARING HEMICALCIUM SALT (E) -7- 4- (4-Fluoro-phenyl) -6-isopropyl-2- Methyl (Methylsulfonyl) AMINO Pyrimidin-5-IL (3R, 5S) -3,5-PIHI-DIHIHI-DIHIHI-DI-DIHIHYTHILEPHYDIN-5-IL-3-5-IL-3-5 6-HEPTENIC ACID

摘要

The method of obtaining hemicaltium salt of rosuvastatin of formula (I), consisting in the extraction of an aqueous solution of sodium or potassium salt (E) -7- [4- (4-fluorophenyl) -6-isopropyl-2- [methyl (methylsulfonyl) amino] pyrimidine-5 -yl] (3R, 5S) -3,5-dihydroxy-6-heptenoic acid, to which sodium or potassium hydroxide or other sodium or potassium salts, which have inorganic anions, may be added with an organic solvent that is not completely miscible with water, which selected from RCOOR, RCOR and ROH, where R and R are respectively hydrogen or C-Saliphatic hydrocarbon, Saromatic hydrocarbon, Sealy Cyclic hydrocarbon or a combination of aliphatic and aromatic or cyclic hydrocarbon, and the resulting extract is mixed with an aqueous solution of inorganic or C-C organic calcium salt, the product of formula I is further isolated by cooling and / or adding an anti-solvent and filtering, and possibly further converted to amorphous form.