METHOD FOR THE GENERATION OF GENETICALLY MODIFIED VERTEBRATE PRECURSOR LYMPHOCYTES AND USE THEREOF FOR THE PRODUCTION OF HETEROLOGOUS BINDING PROTEINS

摘要

The present invention generally relates to the fields of genetic engineering and antibody production. In particular, it relates to the generation of genetically modified vertebrate precursor lymphocytes that have the potential to differentiate into more mature lymphoid lineage cells, and to the use thereof for the production of any heterologous antibody or binding protein.