REGULATION OF FOOD INTAKE AND GLUCOSE PRODUCTION BY MODULATION OF LONG-CHAIN FATTY ACYL-CoA LAVELS IN THE HYPOTHALAMUS

摘要

Methods of reducing food intake and glucose production in a mamma], or restoring hepatic auto regulation are provided. The methods involve increasing long-chain fatty acyl-Co A (LC-CoA) levels in (he hypothalamus. or stimulating efferent fibers in the hepatic branch of the vagus nerve. Also provided are methods of increasing food intake and glucose production in a mammal. The methods involve decreasing long-chain fatty acyl-Co-A (LC-CoA) levels in the hypothalamus of the mammal.