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CLINICALLY RELEVANT ANIMAL MODEL OF HUMAN BREAST CANCER AND VEGF INVOLVEMENT IN DESMOPLASTIC RESPONSE, TAMOXIFEN RESISTANCE AND METASTASIS
CLINICALLY RELEVANT ANIMAL MODEL OF HUMAN BREAST CANCER AND VEGF INVOLVEMENT IN DESMOPLASTIC RESPONSE, TAMOXIFEN RESISTANCE AND METASTASIS
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机译:人乳癌的临床相关动物模型和VEGF侵袭去塑反应,他莫昔芬耐药和转移
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摘要
Expression of VEGF correlates with clinically aggressive, tamoxifen resistant metastatic breast cancer. To assess the role of VEGF expression on breast cancer growth, metastasis and development of anti-estrogen resistance, and desmoplasia an ER-positive, several MCF-7-derived cell lines, designated C9V, were engineered to express VEGF in a doxycycline-regulated manner. C9V cells were introduced into a athymic nude mouse to produce a xenograft model of breast cancer. Expression of VEGF in xenografts increased neoangiogenesis, enhanced tumor growth, stimulated a tamoxifen resistant phenotype, increased metastatic potential and induced a desmoplastic response. These results suggest that inhibition of VEGF expression or action will be effective in the treatment of breast cancer. In addition, inhibition of VEGF expression or action with inhibition of estrogen expression or action may also be effective.
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