NOVEL COMPOUNDS FOR THE MANAGEMENT OF AGING RELATEDE AND DIABETIC VASCULAR COMPLICATIONS,AND THERAPEUTIC USES THEREOF

摘要

THE INVENTION DISCLOSESW NOVEL COMPOUNDS LF THE4 PYRIDINIUM SERIES USEFUL FOR THE MANAGEMENT OF DIABETES AND AGIING RELATED VASCULAFR COMOPLICATIONS, INCLUDING KIDNEY DISEASE, NERVE DAMAGEM, ATHEROSCLEROSIS, RETINOPATHY,DERMATOLOGICAL DISORDERS AND DISCOLORATION OF TEETH. BY BREAKING PREFORMED AGE, OF THE GENER5AL FORMULA I, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF FIG (1) WHEREIN R1,R2,R3,X ANMD MARE AS DEFINED IN THE SPECIFICATION. THE INVENTION ALSO DISCLOSES, MEHTOD FOR PREPARATI0NM OF THE NOVAL COMPOUNMDS OF THE SERIES AND PHARMACEUTICAL COMPOSITION HAVING ONE OR MORE COMPOUNDS AS DEFINED ABOVE AS ACTIVE INGREDIENTS. THE INVENTION FURTHER DISCLOSES A METHOD OF TREATMENT OF A DIABETIC PPATIENT BY ADMINISTERING THE COMPOUNDS ASW DEFINED ABOVE, EITHER SINGLY OR IN COMBINATION WITH DRUGS FOR ANTIDIABETIC THERAPY.