Novel compounds for the management of aging-related and diabetic vascular complications, their preparation and therapeutic use

摘要

The invention discloses novel compounds of the pyridinium series useful for the management of diabetes and aging-related vascular complications, including kidney disease, nerve damage, atherosclerosis, retinopathy, dermatological disorders and discoloration of teeth, by breaking preformed AGE, or pharmaceutically acceptable salts thereof. The invention also discloses, method for preparation of the novel compounds of the series and pharmaceutical composition comprising one or more of these compounds. The invention further discloses a method of treatment of a diabetic patient by administering the compounds either singly or in combination with drugs for antidiabetic therapy.