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METHOD OF TREATMENT AND BIOASSAY INVOLVING MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) AS CARDIAC-DERIVED MYOCARDIAL DEPRESSANT FACTOR.
METHOD OF TREATMENT AND BIOASSAY INVOLVING MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) AS CARDIAC-DERIVED MYOCARDIAL DEPRESSANT FACTOR.
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机译:涉及巨噬细胞迁移抑制因子(MIF)作为心脏源性心肌抑制因子的治疗和生物测定方法。
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摘要
One embodiment of the present invention relates to a pharmaceutical composition, which includes a therapeutically effective amount of at least one anti-MIF antibody; and at least one pharmaceutically acceptable carrier. Another embodiment of the present invention relates to a pharmaceutical composition, which includes a therapeutically effective amount at least one anti-CD74 antibody; and at least one pharmaceutically acceptable carrier. Another embodiment of the present invention relates to a pharmaceutical composition, which includes a therapeutically effective amount of at least one anti-TNFR antibody; a therapeutically effective amount of at least one anti-MIF antibody; and at least one pharmaceutically acceptable carrier. Other embodiments of the present invention relate to methods of treating or preventing cardiac dysfunction, cardiodepression, burn injury-associated cardiac dysfunction, improving cardiac function in a subject following acute myocardial infarction, and identifying an MIF inhibitor.
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