Co-therapy for the treatment of migraine comprising a topiramate and a triptan

摘要

Disclosed herein is a use of a sulfamate compound of formula (I) (such as a topiramate): wherein: X is CH2 or oxygen; R1 is hydrogen or alkyl; and R2, R3, R4 and R5 are as defined in the specification, for the manufacture of a medicament for treating migraine in a subject in need thereof, wherein said medicament further comprises a therapeutically effective amount of a triptan (wherein the triptan may be selected from the group consisting of sumatriptan, naratriptan, rizatriptan, zolmitriptan, eletriptan, frovatriptan and almotriptan), or said medicament is for administration in combination with a therapeutically effective amount of a triptan.