Primary cultured adipocytes for gene therapy to which a foreign gene has been transferred

摘要

Primarily cultured adipocytes for gene therapy which stably sustain a foreign gene encoding a protein secreted extracellularly. Namely, cells appropriate for gene therapy, which are usable as a substitute for bone marrow cells or hepatocytes having been employed in ex vivo gene therapy, are provided. Thus, a method of transferring a foreign gene into primarily cultured adipocytes appropriate for ex vivo gene therapy, which can be easily collected and transplanted and can be eliminated after the transplantation, is established. In particular, primarily cultured adipocytes appropriate for ex vivo gene therapy which stably sustain a foreign gene encoding a protein secreted extracellularly are established.