Compounds derived from 1 - aza - biciclononano as cholinergic ligands for the nicotinic acetylcholine receptor (nAChR)

摘要

Refers to compounds derived from 1 - aza - biciclononano of formula (i) where X is H or hydroxyl; and is a compound of formula (a), (b), (c) or (d). Preferred compounds are: (4S, 5R) - 4 - [5 - (1h indole - 5 - il) - pyrimidin-2-yl] - 1 - 2 - iloxi - aza Bicyclo [3.3.1] nonane, 5 - {2 - [(4S, 5R) - (AZA Bicyclo [- 1 - 3.3.1] - non - 4-yl) oxy] pyrimidin-5-yl) - 1,3 Dihydro indole - 3 - ona, (4S, 5R) - 4 - [6 - (1h indole - 5 - il) - pyridin - 3 - iloxi] - 1 - aza Bicyclo - [3.3.1] nonane, among others. Also relates to a preparation method and a Pharmaceutical composition.These compounds are ligands of cholinergic nicotinic acetylcholine receptor (nAChR) being useful in the treatment of Alzheimer's disease, Attention Deficit Disorder, Parkinson's disease, Psychosis, depression