首页> 外国专利> Pharmaceutical synthesis containing 1 - 4 - (2-azepan-1-il-etoxi) - bencil - 2 - (4-hydroxifenil) - 3-methyl-1h-indol-5-ol acetic (bazedoxiphen acetate) as a selective modulator of estrogen receptor

Pharmaceutical synthesis containing 1 - 4 - (2-azepan-1-il-etoxi) - bencil - 2 - (4-hydroxifenil) - 3-methyl-1h-indol-5-ol acetic (bazedoxiphen acetate) as a selective modulator of estrogen receptor

机译:包含1- [4-(2-氮杂-1--1-乙-甲苯磺酸)-苯环] -2-(4-羟基苯乙腈)-3-甲基-1h-吲哚-5-醇乙酸(乙酸巴泽多芬)的药物合成药物雌激素受体调节剂

摘要

It refers to a kind of drug synthesis, including: (a) acid 1 - [4 - (2-azepan-1-il-etoxi) - bencil] - 2 - (4-hydroxifenil) - 3-met-1h-indol-5-ol acetic (acetic acid of bazedoxiphen) as a form of crystalline polymorphone, with a content of 0.1-30% by weight of preparation; (b) as the first filling / diluent of sugar, Microcrystalline cellulose, starch, etc., the content is 5-85% by formula weight; (c) the content of the second filling / diluent, such as lactose, is 5-85% by formula weight; (d) An antioxidant, such as acido ascorbico, with a content up to 15% by weight of the formula;(e) A sliding / decomposing agent, such as starch glycerin, containing between 0.01% and 10% by formula weight; F) lubricating oil, such as magnesium stearate, containing between 0.01% and 10% by formula weight. He also mentioned a procedure for preparing music. As a selective modulator of estrogen receptor, diacetate is very useful in the treatment of postmenopausal osteoporosis.
机译:它指的是一种药物合成方法,包括:(a)酸1-[4--(2-氮杂-1-苯乙酮)-苯甲酸]-2-(4-氢苯芬尼)-3-met-1h-吲哚结晶形式的吗啡酮形式的-5-ol乙酸(巴泽昔芬的乙酸),含量为制剂重量的0.1-30%; (b)作为糖,微晶纤维素,淀粉等的第一填充/稀释剂,含量为配方重量的5-85%; (c)第二填充剂/稀释剂(例如乳糖)的含量为配方重量的5-85%; (d)抗氧化剂,例如抗酸抗坏血酸,其含量不超过配方重量的15%;(e)滑动/分解剂,例如淀粉甘油,含量不超过配方重量的0.01%至10%; F)按重量计含有0.01%至10%的润滑油,例如硬脂酸镁。他还提到了准备音乐的程序。作为雌激素受体的选择性调节剂,二乙酸酯在绝经后骨质疏松症的治疗中非常有用。

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