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IONTOPHORETIC DELIVERY OF ROTIGOTINE FOR THE TREATMENT OF PARKINSON`S DISEASE
IONTOPHORETIC DELIVERY OF ROTIGOTINE FOR THE TREATMENT OF PARKINSON`S DISEASE
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机译:离子促排剂旋转蛋白的治疗帕金森氏病
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摘要
By using a composition comprising rotigotine and at least one chloride salt in a concentration of 1 to 140 mmol/l, the composition having a pH of 4 to 6.5 in a iontophoretic device for the treatment of Parkinson's disease, it became possible to obtain a rotigotine flux across the human stratum corneum which was higher than the one previously obtained with conventional passive diffusion systems.
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