Indolines carrying vehicles Andwlyn alternatives works to inhibit the enzymes tyrosine kinase receptor tyrosine kinases

摘要

Abstract: the present invention relates to compounds Andwlynwn indolinones as: inhibitory effect has inhibitory effect on the enzyme tyrosine kinase receptor receptor tyrosine kinases Wmtrakbat doxycycline / CDK Cyclin / CDK complexes in addition to endothelial cells Altathyralmthbt on the proliferation of endothelial cells and tumor cells tumor cells, examples include: (a) 3-Z. [1 - (4 - (Bybrydynyl (1) Anylynw methyl) - 1 - phenyl - MS Expression of] the Athwksy CR.Notes - 2 - Andwlynwn Z 3L - (4 - (piperidin-l-yl-methyl). Anilino). L.] - 2-phenyl methylene]. 6-ethoxycarbonylindolinone, (b) 3-Z - [1 - (4 -) Bybrydynyl (I) - methyl) - Anylynw. Phenyl Mthylyn]. The Krbamwyl II. L (4 - (piperidin] l-yl-methyl). Anilino). L-phenyl-me Thylene] - [6-carbamoyl-2-4). L