Carboxymethylated pyridoindoles, process for their preparation and their use as aldose reductase inhibitors and as antioxidants

摘要

The essence of the invention is the use of carboxymethylated pyridoindoles of the general formula (I), where R, R', R1, R1', R3, R3', R4, R4', R6-R9 = H, R2 = CH3, CH2C6H5, CH2CH2C6H5 and M = H , respectively metal cation of physiologically acceptable salts for the manufacture of a medicament for preventing and treating medical conditions, where an aldose reductase inhibition and elimination of oxidative stress is desirable - to prevent and treat complications associated with diabetes mellitus such as diabetic cataract, diabetic retinopathy, diabetic neuropathy, diabetic nephropathy, diabetic cardiomyopathy, diabetic microangiopathy and diabetic macroangiopathy in humans and mammals.