PARTICLES WRAPPED OF VIRAL DNA PRE-REPLICATION OF VIRUS DE HERPES.

摘要

A PREPARATION OF A PARTICULATE OF VIRUSES, SUBSTANTIALLY FREE OF VIRIONS, BASED ON PARTICLES OF A HERPESVIRUS, ESPECIALLY VSH-1, WHICH ARE RELATED TO THE VIRUS, NON-INFECTIVE HERPESVIRUS PARTICLES A MORE SPECIALLY VIRUS OF THE HERPES SIMPLE 1 OR 2, IN CHARGE OF A CAPSIDA AND VIRAL DNA, CHARACTERIZED IN WHICH THEY ARE PRE- (REPLICATION OF VIRAL DNA) PARTICULATING (SPERP) BY CAREING OR CONTAINING ONLY SMALL QUANTITIES OF AT LEAST ONE OF THESE PROTEINS THAT ARE REAL LATE NORMALLY ONLY AFTER THE REPLICATION OF VIRAL DNA. THEY CAN BE PREPARED BY INFECTING CELLS GUESTED WITH A HERPESVIRUS TO PREVENT THE REPLICATION OF VIRAL DNA, BUT ALLOWING THE SYNTHESIS OF VIRAL PROTEINS AND FORMATION OF PARTICLES AND THE RECOVERY OF A SPERP SUBSTANTIALLY FREE OF VIRIONS.