PROFARMACOS 9,11-CYCLOENDOPEROXIDE OF PROSTAGLANDIN ANALOGS FOR THE TREATMENT OF OCULAR HYPERTENSION AND GALUCOMA.

摘要

Use of a compound for the manufacture of a medicament for therapeutic application in order to decrease the intraocular pressure in the eye of a mammal, compound having the formula (See formula) in which the dotted lines represent the presence of a bond or the absence of a link, the wavy lines represent the alpha or beta configuration, the black triangles represent the beta configuration and the shaded lines represent the alpha configuration; n is an integer that has values from 1 to 6; m is an integer that has values from 1 to 8; X is NH2, N (R) 2, NHR or OR, where R is hydrogen, R4 or a group - (CO) R4; Y is = O, = S or OH, OR5 or -O (CO) R5 groups, said OH, OR5 or O (CO) R5 groups being attached to the adjacent carbon atom in the alpha or beta configuration; R1 is H, CH3, R7, OR7 or SR7, in which R7 is an aliphatic, aromatic or heteroaromatic ring, heteroaromatic ring having 1 to 3 heteroatoms selected from O, S and N, aliphatic, aromatic or heteroaromatic ring that optionally is substituted with 1 to 3 R8 groups, in which R8 is F, Cl, Br, I, NO2, C1-6 alkyl, 1-6 alkyl substituted with fluorine, COOH, or COOR9 in which R9 is alkyl of 1 at 6 carbon atoms or CH2OCH3; R2 and R3 together represent = O, = S or, independently, are hydrogen or alkyl of 1 to 6 carbon atoms; R4 represents (CH2) rOH, (CH2) rOCOR9 or (CH2) rOR9, where r is an integer that has values from 1 to 6, or R4 represents saturated or unsaturated acyclic hydrocarbons having 1 to 20 carbon atoms , or - (CH2) q R6, in which q is 0-10 and and R6 is an aliphatic, aromatic or heteroaromatic ring, heteroaromatic ring having 1 to 3 heteroatoms selected from O, S and N, aliphatic, aromatic ring or heteroaromatic which is optionally substituted with 1 to 3 R8 groups, where R8 F, Cl, Br, I, NO2, C1-6 alkyl, C1-6 alkyl substituted with fluorine, COOH, COOR9 where R9 is alkyl of 1 to 6 atoms of carbon or CH2OCH3; R5 represents saturated or unsaturated acyclic hydrocarbons having 1 to 20 carbon atoms, or - (CH2) q R6, or a pharmaceutically acceptable salt of said compound.