The 9,11-cycloendoperoxide prodrugs of prostaglandin analogues for treatment of ocular hypertension and glaucoma

摘要

9,11 Cycloendoperoxide derivaties of biologically active prostaglandin analogs, and particulary of the ocular hypotensive drugs Bimatoprost, Latanaprost, Unoprostone, Travoprost and prostaglandin H₂ 1-ethanolamide or of structurally closely related analogs, are pro-drugs which hydrolyze under physiological conditions to provide prostaglandin analogues that are capable of providing sustained ocular and other in vivo concentrations of the respective drugs.