Inhibitors of nuclear protein interaction / nuclear receptor.

摘要

The invention relates to a method of identifying inhibitor compounds capable of reducing the interaction between a first region constituting the signature of a nuclear protein, and a second region constituting the part of said nuclear receptor capable of interacting with said protein. nuclear, by fixing to said signature reason. The nuclear protein is a connection factor, responsible for the interaction between a nuclear receptor with ligand and a transcription initiation complex involved in the regulation of gene expression. The nuclear receptor is a transcription factor. The signature motif is a short sequence of amino acid residues, which constitutes the key structural element of a nuclear protein that binds to a nuclear receptor with ligand, depending on the process of activation or repression of target genes.