DERIVATIVES OF BENCILIDEN-1,3-DIHIDRO-INDOL-2-ONA AS INHIBITORS OF THE TYPEOSINE KINASE CLASS RECEPTORS, PARTICULARLY OF RAF KINASES.

摘要

A compound of ** formula **, wherein: R1 is H or optionally binds R2 to form a fused ring selected from the group consisting of five to ten membered aryl, heteroaryl or heterocyclyl rings, said heteroaryl rings having or heterocyclyl of one to three heteroatoms where zero to three of said heteroatoms are N and zero to 1 of said heteroatoms are O or S and where said condensed ring is optionally substituted with one to three of R9, where R2 and R9 are as they are defined below; R2 and R3 are independently H, HET, aryl, a C1-12 aliphatic group, CN, NO2, halogen, R10, -OR10, -SR10, -S (O) R10, - SO2R10, -NR10R11, -NR11R12, -NR12COR11 , -NR12CO2R11, - NR12CONR11R12, -NR12SO2R11, -NR12C (NR12) NHR11, -COR11, - CO2R11, -CONR12R11, -SO2NR12R11, -OCONR12R11, C (NR12) NR12R11 where said C1-12 aliphatic group optionally has two units from one to two groups selected from C (O), O, S, S (O), SO2 or NR12; said HET, aryl or C1-12 aliphatic group being optionally substituted with one to three of R10; and wherein R2 optionally binds to R3 to form a condensed ring selected from the group consisting of five to ten membered aryl, heteroaryl or heterocyclyl rings, said heteroaryl or heterocyclyl rings having from zero to three heteroatoms where from zero to three of said heteroatoms are N and zero to one of said heteroatoms are O or S and where said condensed ring is optionally substituted with one to three of R9, where HET, R9, R10, R11 and R12 are as defined below; R4 is H, halogen, NO2 or CN; R5 is H or a C1-12 aliphatic group optionally substituted with one to three of halo, hydroxyl, heteroaryl or aryl; R6 and R7 are halogen; and pharmaceutically acceptable salts or solvates thereof.