A vaccine composition comprising one or more excipients, adjuvants, buffers, carrier proteins or preservatives or a combination thereof and an immunogenic agent, wherein the immunogenic agent is constituted by one or more OspC polypeptides of each of the families. from Borrelia burgdorferi OspC that are selected from the group consisting of: A, B, I and K, in which the Borrelia burgdorferi OspC family A is characterized by GenBank accession number AF029860 and ospC genes that have an identity of At least 98% with GenBank accession number AF029860, Borrelia burgdorferi OspC family B is characterized by the GenBank accession number AF029861 and ospC genes that have an identity of at least 98% with the accession number of GenBank AF029861, the OspC family I of Borrelia burgdorferi is characterized by the GenBank accession number AF029869 and ospC genes that have an identity of at least 98% with the Gen accession number Bank AF029869 and the OspC K family of Borrelia burgdorferi are characterized by the GenBank accession number U08284 and ospC genes that have an identity of at least 98% with the GenBank accession number U08284.
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