THERAPEUTIC COMBINATION OF AMLODIPINA AND BENAZEPRIL / BENAZEPRILAT.

摘要

The use of a combination comprising (1) an ACE inhibitor, selected from the group consisting of benazepril, benazeprilat and pharmaceutically acceptable salts thereof, and (2) amlodipine or a pharmaceutically acceptable salt thereof, for the manufacture of a medication for the treatment or prevention or delay of the progression of a selected state of hypertension, angina, myocardial infarction, atherosclerosis, diabetic nephropathy, diabetic cardiac myopathy, renal insufficiency, peripheral vascular disease, left ventricular hypertrophy, cognitive dysfunction, cerebrovascular disease related to blood pressure, stroke, lung disease or pulmonary hypertension and migraine; wherein (i) the amount of amlodipine or a pharmaceutically acceptable salt thereof corresponds to 6 mg to 40 mg of the free base, and (ii) the amount of the ACE inhibitor or a pharmaceutically acceptable salt thereof corresponds to from 20 mg to 160 mg of benazepril hydrochloride.