DERIVATIVES OF DIHYDROPIRROLO-1,2-AIINDOL AND TETRAHYDROPIRIDE -1,2-AIINDOL AS ANTAGONISTS OF PROSTAGLANDIN RECEPTORS D2.

摘要

A compound having the ** formula ** and pharmaceutically acceptable salts and hydrates thereof, in which: R1, R2 and R3 are each independently selected from hydrogen and Rg; R4 is selected from H, CN, (C1-6) alkyl optionally substituted by one to six halogen, ORa and S (O) n ((C1-6) alkyl); R5 is selected from H and (C1.6) alkyl optionally substituted by one to six halogens; or R4 and R5 together represent an oxo; or R4 and R5 taken together form a 3 or 4 member ring containing 0 or 1 heteroatom selected from NRf, S and O optionally substituted by one or two groups selected from F, CF3 and CH3; R6 is selected from H and (C1.6) alkyl optionally substituted by one to six groups independently selected from ORa and halogen, Ar is aryl or heteroaryl each optionally substituted by one to four groups independently selected from Rg; A is (C1-3) alkyl optionally substituted by one to four halogen atoms, O (CH2) 1-2, S (CH2) 1-2; Q is selected from: (1) COOH, (2) CONRaRb, (3) C (O) NHSO2Rc, (4) SO2NHRa, (5) SO3H, (6) PO3H2 and (7) tetrazolyl, Y1 is ¿(CRdRe) a ¿X¿ (CRdRe) b¿, phenylene, cycloalkylidene (C3¿6) or cycloalkylene (C3¿6), a and b being whole numbers 0¿1 such that the sum of a and b is equal to 0, 1 or 2; X is a bond, O, S, NRa, C (O), OC (O), C (O) O, C (O) NRa, OC (O) NRa, NRaC (O), CRd = CRe or C = C; Y2 is CRdRe, CRdRe¿CRdRe or CRd = CRe.