CONTRACT AGENTS FOR DIAGNOSIS BY IMAGE WITH LONG BLOOD RETENTION.

摘要

THIS INVENTION PROVIDES CONTRAST AGENTS FOR DIAGNOSIS FOR THE IMAGE WITH PROLONGED BLOOD RETENTION. THE NEW COMPOUNDS ARE: A POTENTIAL PART OF THE IMAGE (OR SIGNAL GENERATOR (PPI); B) A PART FOR THE PLASMATIC PROTEIN UNION (PUPP); AND C) A PART PROLONGING THE BLOOD SEMIVIDE (PPSS). THIS INVENTION ALSO REFERS TO THE PHARMACOLOGICAL COMPOSITIONS OF THESE COMPOUNDS AND THE METHODS OF USE OF THE COMPOUNDS AND COMPOSITIONS TO PROLONG THE BLOOD SEMIVIDE AND TO ENHANCE THE CONTRAST IN THE DIAGNOSIS BY IMAGE. THESE CONTRACTING AGENTS SHOW A REDUCED RENAL AND HEPATOCELLULAR RECAPTATION INDEX AND APPEARINGLY ARE LOOKING FOR THE RE. THESE AGENTS CAN GO TO THE BLOOD OR ANOTHER BIOLOGICAL COMPONENT. AS THE AGENT DISAPPEARS WITH LOWER RAPIDITY OF THE BLOOD CURRENT, LOWER DOSE CAN BE USED WITH A LARGER SAFETY MARGIN. THIS APPROACH IS COMMON TO BOTH MOLECULES AND TO SMALL.