New recombinant vector derived from modified Ankara virus, useful in vaccines for treatment or prevention of HIV infection, expresses two separate HIV proteins

摘要

Recombinant vector (A) derived from modified Ankara virus (MVA) that expresses simultaneously (i) a form of the Env protein of HIV-1 that lacks the region corresponding to the whole of gp41 and (ii) a fusion protein (FP) containing sequences of the Gag, Pol and Nef genes of HIV-1, where the sequences encoding (i) and (ii) are under control of identical promoters and are inserted into the same site in the vector. Independent claims are included for the following: (1) similar vector (A1) in which FP and the Gag-Pol-Nef fusion are from simian immune deficiency virus (SIV); (2) recombinant vector (A2) derived from NYVAC virus having the same genomic organization, insertion sites and promoters as (A1); and (3) plasmid (P) used as intermediate for construction and/or characterization of (A1). ACTIVITY : Ant-HIV. No details of tests for anti-HIV activity are given. MECHANISM OF ACTION : Vaccine.