DERIVATIVES OF 1,2,3,4,7,8-HEXAHIDRO-6H- (1,4) DIAZEPINO (6,7,1-IJ) QUINOLINA AS ANTI-PSYCHOTIC AND ANTI-OBESITY AGENTS.

摘要

Compound of formula I in which: R 1 is hydrogen or alkyl of 1 to 6 carbon atoms; R2 and R3 are each independently hydrogen, hydroxy, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, halogen, carboxamido, carboalkoxy of two to six carbon atoms, perfluoroalkyl of 1-6 atoms carbon, cyano, alkanesulfonamido of 1-6 carbon atoms, alkanesulfonyl of 1-6 carbon atoms, alkanamide of 1-6 carbon atoms, amino, alkylamino of 1-6 carbon atoms, dialkylamino of 1-6 atoms of carbon by alkyl moiety, perfluoroalkoxy of 1-6 carbon atoms, alkanoyloxy of 2 to 6 carbon atoms, alkanoyl of 2 to 6 carbon atoms, aroyl of 6 to 8 carbon atoms, aryl of 5 to 7 carbon atoms , a C6 to C13 alkylaryl group having 5 to 7 carbon atoms in the aryl moiety, a 5- to 7-membered heteroaryl group, or a 6 to 13-member alkylheteroaryl group having 5 to 7 members in the heteroaryl moiety ; wherein any R2 or R3 substituent having an aryl or heteroaryl moiety may be optionally substituted, in the aryl or heteroaryl moiety, with 1 to 3 substituents independently selected from a halogen atom, a C1-C6 alkyl group, or a group C1-C6 alkoxy; R4 and R5 are independently hydrogen or alkyl of 1 to 6 carbon atoms; or R4 and R5, taken together with the carbon atoms to which they are attached, form a cyclic moiety selected from a cycloalkane of 4 to 8 carbon atoms, cycloalkene of 4 to 8 carbon atoms, bicyclic alkane bridge of 5 to 10 carbon atoms, bicyclic bridge alkene of 5 to 10 carbon atoms, pyran or thiopyran, in which the sulfur atom is optionally oxidized to sulfoxide or sulfone; wherein the cyclic moiety formed by R4 and R5 may be optionally substituted with 1 to 3 substituents independently selected from a halogen atom, from a C1-C6 alkyl group, or from a C1-C8 alkoxy group; R6 and R7 are each independently hydrogen or alkyl of 1 to 6 carbon atoms; and n is 1 or 2; or a pharmaceutically acceptable salt thereof.