MANGANESE COMPLEXES OF NITROGEN-CONTAINING MACROCYCLIC LIGANDS EFFECTIVE AS CATALYSTS FOR DISMUTATING SUPEROXIDE

摘要

The present invention is directed to lowmolecular weight mimics of superoxide dismutase (SOD)represented by the formula:(see formula I)wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5,R6, R'6, R7, R'7, R8, R'8, R9, and R'9 and X, Y, Z and nare as defined herein, useful as therapeutic agents forinflammatory disease states and disorders,ischemic/reperfusion injury, stroke, atherosclerosis,hypertension and all other conditions of oxidant-inducedtissue damage or injury.