MANGANESE OR IRON COMPLEXES OF NITROGEN-CONTAINING MACROCYCLIC LIGANDS EFFECTIVE AS CATALYSTS FOR DISMUTATING SUPEROXIDE

摘要

Low molecular weight mimics ofsuperox-ide dismutase (SOD) represented by formula (I),wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4,R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, andR'9, M, X, Y, Z and n are as defined herein,use-ful as therapeutic agents for inflammatory diseasestates and disorders, ischemic/reperfusion injury,stroke, atherosclerosis, and all other conditions ofoxidant-induced tissue damage or injury.