A BIOLOGIC MATERIAL COMPRISING AN EFFICIENT CULTURE OF BONE MARROW STEM CELLS PARTIALLY OR COMPLETELY DIFFERENTIATED INTO CONNECTIVE TISSUE CELLS AND A THREE-DIMENSIONAL BIOCOMPATIBLE AND BIODEGRADABLE MATRIX CONSISTING OF A HYALURONIC ACID DERIVATIVE

摘要

A biologic material comprising the following two components: a) an efficientculture of autologous or homologous bone marrow stemcells partially or completely differentiated into connective tissue specificcells further comprising the extracellular matrix secreted by saidconnective tissue cells, or alternatively: a') the extracellular matrixsecreted by: bone marrow stem cells partially or completely differentiatedinto a specific connective tissue, or alternatively, the specific homologousmature connective tissue cells, said extracellular matrix being freefrom any cellular component, and b) a three-dimensional biocompatible andbiodegradable matrix consisting of a hyaluronic acid derivative.The processes for preparing said biologic material and the use thereof intissue grafts.