ACYLPYRROLDICARBOXYLIC ACIDS AND ACYLINDOLDICARBOXYLIC ACIDS AND THEIR DERIVATIVES AND INHIBITORS OF THE CYTOSOLIC PHOSPHOLIPASE A2

摘要

New antiphlogistic andanalgesic agents are disclosedhaving the formulas (I) and(II). These new compoundshave an improved inhibitingeffect and/or less cytotoxicity ascompared with the compoundsknown from the prior art.The disclosed compounds areremarkably suitable to preventand/or treat diseases caused oraggravated by an increased activity of the phospholipase A2 enzyme, such asinflammations, allergies, asthma, psoriasis and endotoxinshock.