COMPOSITE BONE GRAFT CEMENT COMPRISING CALCIUM SULFATE DIHYDRATE AND BRUSHITE

摘要

The invention provides a particulate composition adapted for forming a bonegraft substitute cement upon mixing with an aqueous solution, including i) acalcium sulfate hemihydrate powder having a bimodal particle distribution anda median particle size of about 5 to about 20 microns, wherein the calciumsulfate hemihydrate is present at a concentration of at least about 70 weightpercent based on the total weight of the particulate composition; ii) amonocalcium phosphate monohydrate powder; and iii) a .beta.-tricalciumphosphate powder having a median particle size of less than about 20 microns.Bone graft substitute cements made therefrom, a bone graft substitute kitcomprising the particulate composition, methods of making and using theparticulate composition, and articles made from the bone graft substitutecement are also provided.