Pharmaceutical compositions comprising a combination of rapamycin or its derivative and pimecrolimus for the treatment of inflammation- and immunologically-mediated diseases

摘要

The present relates to pharmaceutical compositions that are useful for the treatment of inflammatory and immunologically mediated diseases, including autoimmune diseases.Claim 1: a Pharmaceutical composition comprising in combination a Derivative of rapamycin and Rapamycin or a compound of the formula (1) wherein R1 is either (a) a group of the formula (2) where R5 is CL, BR, I, or azido Hydroxy or methoxy; R6 R4 is Hydroxy, and is a Link IND Ividual at position 10, 11; or is absent, and there is a double BOND at position 10, 11R1 is a group or (b) or (c) of formulas (3) where R6 are as defined above, and R4 is Hydroxy and there is an individual link in position 1, R2 is oxo and an individual link in position 23, 24; Hydroxy optionally protected and there is an individual link a or B. And link in position 23, 24; or is absent and there is a double BOND at position 2324; R3 is Methyl, Ethyl, propyl or Allyl, and at least a pharmaceutically acceptable excipient.