LIGANDS THAT BIND TO THE AMYLOID-ß PRECURSOR PEPTIDE AND RELATED MOLECULES AND USES THEREOF

摘要

The present invention provides a composition comprising an isolated F-spondin polypeptide specifically bound to an APP or APLP polypeptide. The present invention further provides a composition comprising an isolated neurexin polypeptide specifically bound to an APP or APLP polypeptide. Also provided are methods of screening for modulators of the binding of an APP or an APLP polypeptide by F-spondin or neurexin proteins. Modulators of the binding of an APP or an APLP polypeptide by F-spondin or neurexin proteins may be useful in the treatment or prevention of AD.