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USE OF STATINS IN THE PREVENTION AND TREATMENT OF RADIATION INJURY AND OTHER DISORDERS ASSOCIATED WITH REDUCED ENDOTHELIAL THROMBOMODULIN
USE OF STATINS IN THE PREVENTION AND TREATMENT OF RADIATION INJURY AND OTHER DISORDERS ASSOCIATED WITH REDUCED ENDOTHELIAL THROMBOMODULIN
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机译:他汀类药物在预防和治疗辐射损伤和内皮素血栓素减少相关的其他疾病中的应用
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摘要
The present invention discloses statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) consistently and significantly increased endothelial cell thrombomodulin protein and functional activity. Statins also abrogated the down regulation of thrombomodulin that occurs in response to radiation injury. These results indicate that preserving or restoring endothelial thrombomodulin expression and function by statins may be useful in a variety of disorders associated with widespread endothelial dysfunction such as sepsis, adult respiratory distress syndrome, and normal tissue radiation injury.
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