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Use of statins in the prevention and treatment of radiation injury and other disorders associated with reduced endothelial thrombomodulin
Use of statins in the prevention and treatment of radiation injury and other disorders associated with reduced endothelial thrombomodulin
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机译:他汀类药物在预防和治疗放射损伤和其他与内皮血栓调节蛋白减少有关的疾病中的用途
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摘要
The present invention discloses statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) consistently and significantly increased endothelial cell thrombomodulin protein and functional activity. Statins also abrogated the down regulation of thrombomodulin that occurs in response to radiation injury. These results indicate that preserving or restoring endothelial thrombomodulin expression and function by statins may be useful in a variety of disorders associated with widespread endothelial dysfunction such as sepsis, adult respiratory distress syndrome, and normal tissue radiation injury.
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