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A BLOOD TEST TO MONITOR THE GENETIC CHANGES OF PROGRESSIVE CANCER USING IMMUNOMAGNETIC ENRICHMENT AND FLUORESCENCE IN SITU HYBRIDIZATION (FISH)
A BLOOD TEST TO MONITOR THE GENETIC CHANGES OF PROGRESSIVE CANCER USING IMMUNOMAGNETIC ENRICHMENT AND FLUORESCENCE IN SITU HYBRIDIZATION (FISH)
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机译:通过原位杂交(鱼)免疫磁富集和荧光监测渐进性癌症的遗传变化的血液测试
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摘要
Amplification and overexpression of theHER-2 oncogene in breast cancer is felt to be stable over the course of disease and concordant between the primary tumor and metastases. Therefore, patients with HER-2 negative primary tumors will rarely receive anti-HER-2 antibody therapy. A very sensitive food test is used to capture circulating tumor cells (CTC's) and evaluate their HER-2 gene status by FISH evaluation. The HER-2 status of the primary tumor and corresponding CTC's is used to assess the ratio of CTC's as a reliable surrogate marker. HER-2 expression of 10 CTC's is sufficient to make a definitive diagnosis of the HER-2 gene status for the whole population of CTC's in patients with recurrent breast cancer.
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