USE OF CATHEPSIN INHIBITORS FOR REVERSING OR PREVENTING RESISTANCE OF A CANCER CELL TO A CYTOTOXIC AGENT

摘要

The present invention provides a composition and method for increasing sensitivity of a cancer cell and to reverse or prevent resistance to a cytotoxic agent. The composition includes an inhibiting agent and, optionally, a cytotoxic agent. The inhibiting agent is present in a sub-lethal dose with respect to the cancer cell in the absence of the cytotoxic agent.