IDENTIFYING LANTIBIOTIC GENE CLUSTERS AND NOVEL LANTIBIOTIC GENES

摘要

This invention provides a method for discovery of new lantibiotic pathways by mining available sequence information and by exploiting conserved regions in lantibiotic biosynthetic enzymes to design probes and PCR primers for analysis of un-studied organisms. We have found that lantibiotic biosynthetic enzymes are broadly distributed in Gram-positive. New pathways are being cloned and sequenced and their lantibiotic products are being defined and disclosed.