首页> 外国专利> NEGATIVE REGULATION OF NK CELL FUNCTIONS BY EAT-2, A SAP-RELATED ADAPTOR EXPRESSED IN INNATE IMMUNE CELLS

NEGATIVE REGULATION OF NK CELL FUNCTIONS BY EAT-2, A SAP-RELATED ADAPTOR EXPRESSED IN INNATE IMMUNE CELLS

机译：EAT-2（一种在天然免疫细胞中表达的SAP相关适配器）对NK细胞功能的负调控

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摘要

The present invention relates to the identification EAT-2 and ERT as novel therapeutic targets for the modulation of innate immune cell functions. More particularly the present invention describes novel methods for modulating innate immune cells-mediated immune response, useful in the treatment of cancer, infectious diseases as well as autoimmune diseases The invention also features EAT-2 deficient and overexpressing transgenic animals, screening assays to identify agents that modulate EAT-2 and ERT activity or expression as well as methods of treatments comprising a modulation of NK cells function

机译：本发明涉及鉴定EAT-2和ERT作为调节先天免疫细胞功能的新型治疗靶标。更具体地，本发明描述了用于调节先天免疫细胞介导的免疫应答的新方法，该方法可用于治疗癌症，传染病以及自身免疫病。本发明的特征还在于EAT-2缺陷和过表达的转基因动物，筛选试验以鉴定试剂调节EAT-2和ERT活性或表达的方法，以及调节NK细胞功能的治疗方法

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公开/公告号WO2006122401A1

专利类型
公开/公告日2006-11-23

原文格式PDF
申请/专利权人 INSTITUT DE RECHERCHES CLINIQUES DE MONTREAL/I.R.C.M.;VEILLETTE ANDRÉ;RONCAGALLI ROMAIN;
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申请/专利号WO2006CA00785
发明设计人 VEILLETTE ANDRÉ;RONCAGALLI ROMAIN;
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申请日2006-05-15
分类号A61K31/713;A01K67/027;A61K31/7105;A61K31/7115;A61K31/712;A61K31/7125;A61P37/04;A61P37/06;C12Q1/02;C07H21/02;C12N15/12;
国家 WO
入库时间 2022-08-21 20:52:08

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