A PROCESS OF PREPARING PREDNISOLONE DEVOID OF STEROID-DERIVED IMPURITIES USING RECOMBINANT E. COLI TRANSFORMED WITH A ?1-DEHYDROGENASE GENE

摘要

The present invention relates to a process of using recombinant E. coli having a ?SUP1/SUP-dehydrogenase gene to prepare prednisolone. Specifically, the present invention relates to a fermentation process of using recombinant E. coli containing a ?SUP1/SUP-dehydrogenase gene to prepare prednisolone that is devoid of steroid-derived impurities.