MODULATION OF THE INTEGRIN-LINKED KINASE SIGNALING PATHWAY PROVIDES BENEFICIAL HUMAN CARDIAC HYPERTROPHY AND POST MYOCARDIAL INFARCTION REMODELING

摘要

Modulation of the integrin-linked kinase (ILK) signaling pathway is used to enhance the remodeling process relevant to a wide range of cardiac diseases. More specifically, a process for mediating a broadly adaptive form of human cardiac hypertrophy and a protective process for post myocardial infarction (MI), both comprising illiciting an overexpression of ILK, are described. Upregulation of ILK is also used in a process for affecting ILK mediated reduction of infarct size and beneficial increase in the left ventricular mass post MI.