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CONTROLLING THE REGIO- AND STEREOSPECIFICITY OF ENZYME CATALYSIS WITH GUIDE MOLECULES
CONTROLLING THE REGIO- AND STEREOSPECIFICITY OF ENZYME CATALYSIS WITH GUIDE MOLECULES
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机译:用指导分子控制酶催化的区域和立体比
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摘要
The present invention is directed to methods for controlling regiospecificity and stereospecificity of enzyme catalysis with guide molecules. The use of guide molecules in biocatalysis of different kind of chiral or achiral chemicals allows the production of chemicals with predetermined chiral/chemical structure. Guide molecules can be used to destroy undesired isomers among the racemic precursor molecules (leaving the target isomer intact) or to produce selected precursor molecules by enzymatic cleavage of the guide molecule activated isomer in the racemic reaction mixture. Guide molecules may be used for controlling drug metabolism in humans/non-humans and also for preparing novel prodrugs.
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