NATURAL AND SYNTHETIC SULFOXIDE, SELENONE AND SELENOXIDE ANALOGS AND POLYMER CONJUGATED FORMS THEREOF FOR THE MODULATION OF ANGIOGENESIS

摘要

The present invention relates to inhibiting angiogenesis with sulfoxide containing compounds, and polymeric forms thereof, in mammals including animals and humans. Sulfoxide containing compounds, and polymeric forms thereof , can be used alone or in combination with standard therapies to inhibit angiogenesis-mediated disorders. The present invention also relates to the combined use of sulfoxide containing compounds, and polymeric forms thereof , with other anti-angiogenesis agents, with various anti- inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer, and with laser, photodynamic therapy for ocular-related disorders such as diabetic retinopathy or age-related macular degeneration.