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REGULATION OF TISSUE FACTOR ACTIVITY BY PROTEIN S AND TISSUE FACTOR PATHWAY INHIBITOR
REGULATION OF TISSUE FACTOR ACTIVITY BY PROTEIN S AND TISSUE FACTOR PATHWAY INHIBITOR
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机译:蛋白质和组织因子通路抑制剂对组织因子活性的调节
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摘要
The present invention relates to methods for the identification of compounds that increase or decrease the inhibitory effect of TFPI on tissue factor activity and/or Factor Xa activity and/or thrombin formation. The invention also relates to methods for the identification of compounds that increase or decrease the co-factor activity of Protein S in TFPI-mediated inhibition of tissue factor and/or Factor Xa activity. The invention also relates to a pharmaceutical composition comprising the compounds identifiable by such methods. The invention also relates to methods for the regulation of tissue factor activity by influencing the interaction between Protein S and Tissue Factor Pathway Inhibitor.
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