Methods and compositions for the stabilization of brain natriuretic peptide (BNP) in blood samples

摘要

The method and composition of new protease inhibitor stabilizer of the present invention description including brain natriuretic peptide (BNP), prevents or significantly decreases in blood basis sample, the especially degradation of the BNP in plasma sample. BNP inhibitor of the invention include D-Phe-Phe-Arg-chloromethylketone (PPACK), D-Phe- experts-Arg-chloromethylketone (PPRACK), acetyl-Lei-Lei-arginal (leupeptin), N (N α-carbonyl-Arg-10N/M-Arg-al) Phe (antipain) and diisopropyl fluorophosphate (DFP) (DFP) either alone or in combination. Inhibitor and combinations thereof, the blood samples being collected that can be introduced directly into before laboratory testing or clinical settings. In addition, inhibitor, alone or in combination, blood-based (for example, plasma) matrix can be added to or increasing external BNP (such as BNP of synthesis), when BNP analysis and control material of quantitative of the preparation for patient blood sample.